Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma
نویسندگان
چکیده
منابع مشابه
Endometrial Carcinoma in a Young Woman: "30 is Not Immune".
Endometrioid adenocarcinoma is the most common form (nearly 80%) of endometrial carcinoma. These tumors are referred to as ‘endometrioid’ because they resemble proliferative phase of the endometrium. It is common in postmenopausal women ([50 years) and presents as abnormal vaginal bleeding [1]. About 1–8% of these carcinomas occur in women less than 40 years. Small numbers of cases have been re...
متن کاملMolecular Biology of Endometrial Carcinoma
The term tumour is understood as a general denomination for newly formed tissue formation or cell populations in an organism that do not develop as a physiological response to external or internal stimuli, show abnormality signs and more or less escape the regulatory influence of the surrounding cells and organism. Currently, a general opinion has been accepted that tumours result from congenit...
متن کاملNew molecular aspects of endometrial carcinoma.
Endometrial cancer is the most commonly diagnosed gynecological cancer and its incidence is increasing worldwide. The number of patients with this disease is likely to continue to grow, including younger patients. It is a complex disease driven by abnormal genetic and epigenetic alterations, as well as environmental factors. Many endometrial cancers show estrogen-dependent proliferation. The ca...
متن کاملParity Correlates with the Timing of Developing Endometrial Cancer, But Not Subtype of Endometrial Cancer
Parity is one of well-known risk factors of endometrial cancer, but it is less clear whether parity is associated with the timing of developing endometrial cancer, and with the incidence of subtype of endometrial cancer. Data on 902 patients including age at diagnosis, age at menarche and menopause, parity and age at last birth from two obstetrics and gynaecology hospitals in China was analysed...
متن کاملMolecular pathology of endometrial hyperplasia and carcinoma.
Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occasionally, a nonendometrioid carcinoma may develop as a result of dedifferentiat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2018
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-18-3241